Weekdays in the MLB season typically offer a smaller selection of games to choose from for your daily Fantasy baseball lineups. This is especially true on April 21, which is also Patriots’ Day in some states, as only six games are scheduled after 6:30 p.m. ET. Despite the limited options, there are still plenty of quality players to consider for your MLB DFS lineups, such as Francisco Lindor, Vladimir Guerrero Jr., Juan Soto, and Manny Machado.
While it might be tempting to load up on high-priced superstars, it’s important to also target value picks that can help balance out your lineup without exceeding your salary cap. These under-the-radar options can be key to success in daily Fantasy baseball. To help you make the best choices for Monday’s MLB DFS slate, be sure to check out the expert advice, strategy, and projections from SportsLine’s Mike McClure.
McClure, a seasoned daily Fantasy player who has won over $2 million in his career, uses a proprietary projection model that takes various factors into account to identify the top value plays. In his most recent picks, McClure highlighted Giants pitcher Logan Webb as a top pitching option, and Webb delivered with an impressive performance. Now, as the 2025 MLB season continues, McClure has locked in his top MLB DFS picks for April 21.
McClure’s Top MLB DFS Picks for Monday, April 21
One of McClure’s top picks for Monday is Matt Olson, available at $4,800 on DraftKings and $2,900 on FanDuel. Olson has been on a hot streak recently, with hits in five straight games and multiple extra-base hits, including home runs. He has a favorable matchup against St. Louis, a team he has historically performed well against.
McClure is also high on outfielder Michael Harris II, priced at $4,400 on DraftKings and $2,700 on FanDuel. Harris has had success against Cardinals pitcher Erick Fedde in the past, and with Fedde struggling at Truist Park, Harris could provide excellent value for your MLB DFS lineups.
McClure also has his eye on an undervalued player who he believes is poised for a breakout performance on Monday. This player could be a difference-maker in tournaments and comes at a reasonable price. To see who it is and get the rest of McClure’s MLB DFS picks, head over to SportsLine now.
Setting Your MLB DFS Lineups for April 21, 2025
With expert analysis and insights from Mike McClure, you can make informed decisions when setting your MLB DFS lineups for April 21. Don’t miss out on the opportunity to gain an edge over the competition and potentially win big in daily Fantasy baseball. Visit SportsLine now to access McClure’s complete player pool and picks for both FanDuel and DraftKings.
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